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Admin27.07.2021

Meaghan Schmidt

The proline-rich region of Alix has the majority of protein-binding sites that link it to various cellular mechanisms see for details on specific amino acids involved in protein interactions.
Admin04.07.2021

The multiple personalities of Alix

In most cases, the lumenal vesicles are delivered into the hydrolytic interior of the lysosome after fusion of the MVB perimeter membrane with the lysosomal membrane ; ;.
309
Admin10.08.2021

The multiple personalities of Alix

Alix also is enriched in virions that are released from cells under the direction of the HIV-1 Gag protein ;.
70010
Admin20.06.2021

The multiple personalities of Alix

Src activates signaling pathways that promote cell survival ; and might be key to inhibiting apoptotic activation by the Alix-ALG-2 complex because Src-mediated hyperphosphorylation of Alix disrupts its membrane association.
1408
Admin02.07.2021

Meaghan Schmidt

Both cell proliferation and cell death pathways are thought to be activated in response to growth factors to ensure that cells stimulated to proliferate will be eliminated unless additional signals for survival are received.
7709
Admin16.06.2021

The multiple personalities of Alix

In yeast, however, tyrosine phosphorylation is uncommon, and mutation of the corresponding tyrosine residue in Bro1 has no effect on MVB sorting.
2209
Admin09.07.2021

Meaghan Schmidt

Recruitment of Alix to the site of MVB sorting is mediated by the CHMP4 subunit of ESCRT-III, which binds directly to the Bro1 domain.
32010
Admin05.07.2021

The multiple personalities of Alix

Whether EGFR is similarly mislocalized upon silencing of Alix is not known.
4900
Admin22.07.2021

The multiple personalities of Alix

Fluid-phase endocytosis of anti-LBPA antibodies by living cells causes lumenal endosomal membranes to adopt a disorganized appearance , which suggests that MVB dynamics are influenced by the content of LBPA in membrane bilayers.